DOI: https://doi.org/10.15368/theses.2020.136
Available at: https://digitalcommons.calpoly.edu/theses/2225
Date of Award
10-2020
Degree Name
MS in Biomedical Engineering
Department/Program
Biomedical and General Engineering
College
College of Engineering
Advisor
Lanny Griffin
Advisor Department
Biomedical and General Engineering
Advisor College
College of Engineering
Abstract
Nanoindentation techniques have not been standardized for use on bone tissues, making comparison of bone material properties obtained via nanoindentation across studies difficult and unreliable. This study determined a set of optimal parameter values for thermal drift correction time, dwell time, and loading rate that can be used to obtain accurate and repeatable material properties from human femoral trabecular bone through experimentation and statistical analysis. All testing was conducted using a single nanoindenter on a single trabeculae, with the assumption that material properties within the individual trabeculae were internally consistent. Parameters not of interest during this study, such as ambient temperature, maximum load, and maximum indentation depth were held constant throughout all experiments. Elastic modulus and hardness data were calculated using the Oliver-Pharr technique. The optimal values for these parameters are as follows: 150 seconds for thermal drift correction time, 30 to 60 seconds for dwell time, and 0.4 to 0.8 mN/s for loading rate.