Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma

Author

Eric W. Tsoi, California Polytechnic State University, San Luis ObispoFollow

DOI: https://doi.org/10.15368/theses.2013.214
Available at: https://digitalcommons.calpoly.edu/theses/1134

Date of Award

12-2013

Degree Name

MS in Polymers and Coatings

Department/Program

Chemistry & Biochemistry

Advisor

Raymond Fernando

Abstract

Glaucoma is the leading cause of blindness in the United States accounting for 9-12% of all cases of blindness. Currently, the front line treatment for glaucoma are prostaglandins that may have to be taken up to several times a day. Even with proper treatment, roughly 11% of the patients using the treatment are non-compliant and lose their vision. In this project, ForSight Laboratories has developed a pharmaceutical drug delivering implant with the capability of sustaining long-term release of a prostaglandin as a new way to treat the condition. This project reports the product development of a polymer drug matrix with a controlled release in order to better treat glaucoma. Accompanying product development, a mathematical model was created in order to strengthen the understanding of the dosage profile and to predict long term dosages.