The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.


Biochemistry | Chemistry

Number of Pages


Publisher statement

United States Patent Number: 6,867,311 B2, Mar. 15, 2005. Also available from the United States Patent and Trademark Office. Website: http://www.uspto.gov.



URL: https://digitalcommons.calpoly.edu/chem_fac/12