"Clean, High-yield Preparation Of S,S- and R,S- Amino Acid Isosteres" by Aslam A. Malik, Todd E. Clement et al.
 

Abstract

The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

Disciplines

Biochemistry | Chemistry

Number of Pages

17

Publisher statement

United States Patent Number: 6,867,311 B2, Mar. 15, 2005. Also available from the United States Patent and Trademark Office. Website: http://www.uspto.gov.

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URL: https://digitalcommons.calpoly.edu/chem_fac/12