Title

Cross-Sectional and Longitudinal Associations of Neighborhood Characteristics with Inflammatory Markers: Findings from the Multi-Ethnic Study Of Atherosclerosis

Author Info

Aydin Nazmi, University of Michigan - Ann Arbor
Ana Diez Roux, University of Michigan - Ann Arbor
Nalini Ranjit, University of Michigan - Ann Arbor
Teresa E. Seeman, University of California - Los Angeles
Nancy S. Jenny, University of Vermont

Recommended Citation

Postprint version. Published in Health & Place, Volume 16, Issue 6, November 1, 2010, pages 1104-1112.

NOTE: At the time of publication, the author Aydin Nazmi was not yet affiliated with Cal Poly

The definitive version is available at https://doi.org/10.1016/j.healthplace.2010.07.001.

Abstract

We investigated cross-sectional associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (n=5370) and longitudinal associations with changes in IL-6 over a 3–4 year period (n=946). In cross-sectional analyses, higher levels of neighborhood deprivation and problems were associated with higher levels of all three inflammatory markers, whereas higher levels of safety were associated with lower levels. Fibrinogen remained associated with all neighborhood characteristics except cohesion and IL-6 remained associated with safety after adjustment for race and SES. In longitudinal analyses, higher levels of neighborhood deprivation and problems, and lower levels of safety were associated with greater longitudinal increases in IL-6 after adjustment for age, sex, race, and SES. These findings were not substantially modified by further risk factor adjustment. Although findings regarding different inflammatory markers were mixed, the longitudinal results that are less limited by race confounding suggest that inflammatory pathways may contribute to neighborhood differences in cardiovascular disease risk.

Disciplines

Food Science | Nutrition

Copyright

2010 Elsevier