Degree Name

BS in General Engineering

Date

4-2015

Advisor(s)

Robert Crockett

Abstract/Summary

Modafinil (Provigil) belongs to a new pharmaceutical class known as eugeroics— wake-promoting agents. Directly enhancing conductance across neuronal membranes, modafinil, amplifies presynaptic Na/Ca influx; resultant widespread depolarization of cortical interneurons could theoretically allow transient, voltage-dependent inhibition of monoamine reuptake- resembling action of conventional stimulants, minus the stereotypy, euphoria, and locomotor effects. This literature review presents a hypothesized mechanism of action, consolidates research of modafinil analogues and hybridizes a novel compound in search of a next generation molecule.

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