College - Author 1
College of Engineering
Department - Author 1
General Engineering Department
Degree Name - Author 1
BS in General Engineering
Date
4-2015
Primary Advisor
Robert Crockett
Abstract/Summary
Modafinil (Provigil) belongs to a new pharmaceutical class known as eugeroics— wake-promoting agents. Directly enhancing conductance across neuronal membranes, modafinil, amplifies presynaptic Na/Ca influx; resultant widespread depolarization of cortical interneurons could theoretically allow transient, voltage-dependent inhibition of monoamine reuptake- resembling action of conventional stimulants, minus the stereotypy, euphoria, and locomotor effects. This literature review presents a hypothesized mechanism of action, consolidates research of modafinil analogues and hybridizes a novel compound in search of a next generation molecule.
URL: https://digitalcommons.calpoly.edu/bmedsp/64