DOI: https://doi.org/10.15368/theses.2013.207
Available at: https://digitalcommons.calpoly.edu/theses/1127
Date of Award
12-2013
Degree Name
MS in Biomedical Engineering
Department/Program
Biomedical and General Engineering
Advisor
Robert B. Szlavik
Abstract
Modification of Hodgkin and Huxley’s experimentally derived set of nonlinear differential equations was implemented to accurately simulate the action potential of the Hirudo Medicinalis’s Retzius cell in MATLAB under analogous conditions to those found in the Retzius cell environment. The voltage-gated sodium and potassium channel responses to changes in membrane potential, as experimentally determined by Hodgkin and Huxley, were manipulated to suit simulation parameters established by electrophysiological Retzius cell recordings. Application of this methodology permitted additional accurate simulation of the Hirudo Medicinalis’s P cell under analogous conditions to those found in the P cell environment. Further refinement of this technique should allow for the voltage-gated behavioral based simulation of action potential waveforms found in variety of neurons under simulation conditions analogous to the nerve cell environment.