August 1, 2012.
Title: Further development of the Chemical Mixture Methodology (CMM) Wizard – an on-line tool
Sarah Horn, University of Colorado, Boulder
The Chemical Mixture Methodology (CMM) program was developed to ensure individuals’ safety in the event of a chemical release into the atmosphere. The CMM uses Health Code Numbers (HCN) and user entered chemical concentrations to calculate hazard indices (HIs). The HIs indicate the level of adverse health effects an individual could experience from exposure to a mixture of chemicals. Current focus is on furthering development of the CMM Wizard, an online application that allows a user to input information about a specific chemical mixture (i.e. chemical names, receptor locations, concentration values) and then calculates the HI for the mixture. The Wizard then displays the results based on the mode of action of the chemicals and the target organs effected by the chemicals. In order to further develop this program, multiple tests have been executed to determine the Wizard’s accuracy and benefit as evidenced by the level of max HI as compared to simply adding HIs for each chemical. The Wizard test results were compared to hand calculations to ensure accuracy. Testing of CMM Wizard is still in progress. Apart from assisting with analysis of the CMM Wizard, other project goals were to compose a user guide and develop a contact page using HTML for the CMM Wizard. One additional goal was to create a user registration page for the CMM using HTML. The CMM Wizard user manual provides users with an easy to understand workable instruction guide along with troubleshooting tips. The CMM Wizard contact page allows users to report problems, pose questions, or submit comments. The registration page allows CMM users to register and receive updates on CMM tools and progress. In the future, a beta version of the CMM Wizard will be released with the user manual and new features.
Pacific Northwest National Laboratory (PNNL)
This material is based upon work supported by the S.D. Bechtel, Jr. Foundation and by the National Science Foundation under Grant No. 0952013. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the S.D. Bechtel, Jr. Foundation or the National Science Foundation. This project has also been made possible with support of the National Marine Sanctuary Foundation. The STAR program is administered by the Cal Poly Center for Excellence in Science and Mathematics Education (CESaME) on behalf of the California State University (CSU).