Biomedical and General Engineering Department
BS in Biomedical Engineering
Coronary Artery Disease (CAD) is responsible for 1 death every minute in the US. Angioplasty with the implantation of stents is a common treatment method for CAD. Although there is a variety of stents currently on the market, there is still a need to develop new types for different pathologic conditions. Preliminary assessment of the physiological response to new stents is needed as they are being developed. The FDA approval process implemented today is a long, tedious path with a range of testing methods that include static in vitro testing and high-cost animal testing. Tissue engineered blood vessels have been used to create "blood vessel mimics" (BVM) as an intermediate step to improve the evaluation process. A previous Cal Poly tissue engineering student, Sarah Ur, developed a BVM protocol as part of her senior project. The aim of my senior project is to investigate the reproducibility of the existing BVM protocol for creating confluent cell linings on the interior lining of a polymer scaffold.