Date

12-2011

Degree Name

BS in Mathematics

Department

Statistics Department

Advisor(s)

Rebecca Ottesen

Abstract

The main objective of this paper is to evaluate possible socio-economic status, clinical, and treatment associations with the occurrence of distant metastasis in Stage I – III breast cancer patients. After analysis in a logistic regression model, four variables were found to be significant with occurrence of distant metastases. These variables were: education, disease group (Triple-negative, Her2Neu-positive and Luminal A), stage at diagnosis, and concordance to chemotherapy based on the NCCN guidelines. Patients without a college degree were found to be more likely to develop distant metastasis than those with a college degree (OR = 2.46 95% CI 1.44 – 4.23). Triple-negative and Her2Neu-positive patients had higher odds of having distant metastasis than those in with luminal A disease (OR = 3.88 and 3.22 95% CI 2.25 – 6.69 and 1.88 – 5.52, respectively). Stage III patients also had higher odds of having distant metastasis than those with Stage I disease (OR = 5.41 95% CI 2.74 – 10.65). Finally, an unusual result was discovered where patients who were not classified to a chemotherapy guideline were significantly less likely to have distant metastasis than their counterparts who received the recommended chemotherapy (OR = .32 95% CI 0.17 - 0.58).

Included in

Biostatistics Commons

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