January 1, 2010.
The definitive version is available at http://dx.doi.org/.
Nanolipoprotein particles (NLPs) have the potential to be versatile platforms for many different kinds of medical applications, from cancer therapeutics to vaccine delivery. These particles can be very useful in medicine because they are composed of molecules that are naturally made by the body and therefore have a lower potential of having harmful side effects. However, there are many questions that are unknown about the function of NLPs within an organism. How long can NLPs circulate within the blood? How stable are NLPs within the blood? At what point do NLPs degrade and is this enough time for them to reach its destination in the body? This particular project tests the stability of NLPs in biological media to understand how NLPs may behave within the blood. Understanding its stability in blood can be useful in cancer therapeutic applications because NLPs can be targeted specifically to cancer cells and deliver drugs directly to the tumor if they are able to degrade only after reaching the target tissue.
Lawrence Livermore National Laboratory (LLNL)