Pre-print version. This article is copyright protected. Any distribution without written consent from S. Karger AG, Basel is a violation of the copyright. Published in Nephron Journal, Volume 13, Issue 5, January 1, 1974, pages 382-389.
Publisher website: http://www.karger.com
NOTE: At the time of publication, the author Susan C. Opava-Stitzer was affiliated with Dartmouth School of Medicine. Currently, April 2008, she is Dean of Research and Graduate Programs at California Polytechnic State University - San Luis Obispo.
Arterial plasma renin activity (PRA) was measured using radioimmunoassay techniques in pentobarbital-anesthetized dogs. Acute saline loading (40-60ml 150mm NaCl/kg body weight, or 20ml 300mm NaCl/kg body weight, i.v.) reduced PRA from control level in 7 dogs. Despite continued increases in filtered and excreted masses of Na, subsequent partial aortic clamping increased PRA in proportion to the degree of reduction in renal perfusion pressure. In 6 other dogs aortic clamping super-imposed on total ureteral occlusion led to changes in PRA which were inversely associated with renal perfusion pressure. These results suggest a controlling mechanism for renin secretion sensitive to some hemodynamic parameter.