Published in United States Patent Number: 6,605,732 B1, April 12, 2003, pages 1-19.
United States Patent Number: 6,605,732 B1, Aug. 12, 2003, 19 pages. Also available from the United States Patent and Trademark Office. Website: http://www.uspto.gov.
NOTE: At the time of publication, the author Hasan Palandoken was not yet affiliated with Cal Poly.
The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.
Biochemistry | Chemistry