Abstract

The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

Disciplines

Biochemistry | Chemistry

Publisher statement

United States Patent Number: 6,605,732 B1, Aug. 12, 2003, 19 pages. Also available from the United States Patent and Trademark Office. Website: http://www.uspto.gov.

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URL: http://digitalcommons.calpoly.edu/chem_fac/14