Title

The Relationship Between Basic Multicellular Unit Activation and Origination in Cancellous Bone

Author Info

C. J. Hernandez, VA Palo Alto Health Care System
S. J. Hazelwood, Stanford UniversityFollow
R. B. Martin, University of California at Davis Medical Center

Recommended Citation

Postprint version. Published in Bone, Volume 25, Issue 5, November 1, 1999, pages 585-587.

NOTE: At the time of publication, the author S.J. Hazelwood was not yet affiliated with Cal Poly.

The definitive version is available at https://doi.org/10.1016/S8756-3282(99)00201-X.

Abstract

Activation frequency is often used as a measure of basic multicellular unit (BMU) activity in cancellous bone. However, activation frequency expresses the rate of BMU appearance in a histologic slide and not the rate of origination, which is a more physiologic indicator of remodeling activity and is necessary for the development of BMU-level bone remodeling simulations. Using identical assumptions to those for calculating the activation frequency, it is shown that the origination frequency in cancellous bone is equal to the activation frequency divided by the total distance traveled by the BMU and its width.

Disciplines

Biomedical Engineering and Bioengineering

Copyright

1999 Elsevier.